As we mentioned above, PEA is most well known for its effects on pain, however, research has also found that a Palmitoylethanolamide supplement may help support cardiovascular function. jar of Palmitoylethanolamide (PEA) Capsules. Palmitoylethanolamide has been shown to potentially be beneficial for various pain states. Get more insight by reading Palmitoylethanolamide reviews below. Retinopathy is an eye disease that can result in vision loss. To get a complete picture of your endocannabinoid genetics, you should also take a look at your cannabinoid receptor genes, CNR1, and the following SNPs in this gene: Note: Make sure you buy Palmitoylethanolamide and NOT Phenylethylamine (a completely different supplement that’s also sometimes referred to as PEA). Neuropathy can be tricky, especially if it becomes chronic. PEA was added to antidepressant treatment (citalopram) and lowered symptoms by an impressive 50% [25]. Don’t get them wrong. Despite their efforts, a number of these studies had major drawbacks (such poor design, low quality, or small sample size). This increases the levels of calming anandamide in your body, helping to combat pain and increase relaxation. Since less FAAH activity will increase anandamide, FAAH is also called the bliss enzyme (ananda = bliss) [2]. PEA should never be used as a replacement for approved medical therapies. Palmitoylethanolamide (PEA) is a fatty acid that is naturally produced by the body in response to inflammation and pain. is a clickable link to peer-reviewed scientific studies. She loves communicating science and empowering people to achieve their optimal health. Their hypothesis remains unproven, though [4]. Get the Regimen of A Top Biohacker Preparing His Body to Fight Coronavirus. However, some scientists say that simply increasing your intake of palmitic acid or other dietary fats will not affect PEA production in the body. Some scientists think PEA might be a histamine-release blocker. There is insufficient evidence to support the use of PEA for any of the below-listed reasons. People respond differently to diets and supplements because everyone has unique DNA. We are dedicated to providing the most scientifically valid, unbiased, and comprehensive information on any given topic. Its effects on seizures have yet to be investigated in humans [19]. PEA contains palmitic acid in its structure. It has been investigated in over 30 clinical trials and a total of ~6k people since the 1970s [3]. We believe that the most accurate information is found directly in the scientific source. PEA is involved in a variety of cellular functions, and has been shown to have neuroprotective, anti-inflammatory, anti-nociceptive (anti-pain) and anti-convulsant properties (1). If you are genetically predisposed to higher FAAH activity, you will likely benefit from PEA. In another study of 600 people with various types of pain (sciatica, arthritis, shingles, cancer, diabetic neuropathy) PEA treatment of 1200 mg/day for three weeks followed by 600 mg/day for four weeks showed the average pain score across all groups decreased from 6.4/10 before treatment to 2.5/10 after treatment! Our science team must pass long technical science tests, difficult logical reasoning and reading comprehension tests. James, on Dec 30, 2017 It also reduces gastrointestinal motility and cancer cell proliferation, as well as protecting the vascular endothelium in the ischemic heart (2). This is because your body will use PEA only when it needs to compensate for inflammation or pain, and its levels will also normally vary throughout the day [4]. If you’re on a meat-heavy diet or are prone to food sensitivities, PEA supplements are a safer and more effective choice. In Italy and Spain, PEA is marketed as a food for special medical purposes [2]. This supplement is found in EVERY healthy cell in your body. You’ll ideally be able to balance your cannabinoids before they cause any problems. It didn’t have any potential to damage cells, cause mutation, or cancer. Required fields are marked *. For example, if you know that you are predisposed to low endocannabinoid levels (high FAAH and/or low CNR1 gene activity), you’re more likely to benefit from PEA. Palmitoylethanolamide (PEA) is produced in the body to combat pain and inflammation. Keep us posted if you try it. FAAH is called the “bliss enzyme” because it breaks down natural cannabinoids. Since its discovery in the 1950s, researchers have been curious about PEA. The PEA supplements have various health benefits to individuals suffering from painful or chronic health disorders. For example, one can go for the bottle containing 60 capsules which is priced at $34.95. In one study, a special PEA formulation (ultramicronized PEA) was given as an add-on to conventional therapy for 12 weeks in 73 people with pain and spasticity associated with spinal cord injury. Przegl Lek. However, these will not be a suitable option for people with food sensitivities. Animal studies revealed how PEA may achieve these benefits. It increased neurotrophic factors (BDNF, NGF), small but powerful proteins that help create new brain cells needed to regenerate tissues after traumatic damage of the spinal cord or brain [16, 18]. In four additional studies, PEA lowered the chances of catching a cold and the severity of symptoms. Rodent research has found that Palmitoylethanolamide promoted cellular function and overall cell proliferation , particularly around heart tissue. Your brain starts to rewire pain signals, thus tamping down the pain can be beneficial (outside of just wanting to function better). It is already available in your body and thus your body handles it well without any possible side effects. Larger studies would need to confirm the safety of PEA in children. Avoid Illness By Using the Best Supplements For Your Body. PEA has also shown some effectiveness against weight gain. But aside from its direct effects on brain cells, PEA is important for brain health due to its action on our endocannabinoid system. Ana spent years working with patients who suffer from various mental health issues and chronic health problems. Ever try supplements that don’t seem to work? Your email address will not be published. SelfHacked has the strictest sourcing guidelines in the health industry and we almost exclusively link to medically peer-reviewed studies, usually on PubMed. Additional studies should explore its effects as a standalone supplement and as an add-on to standard therapy [4]. It has been shown to have neuroprotective, anti-inflammatory, anti-nociceptive (anti- pain) and anti-convulsant properties. However, more research is needed to determine PEA’s exact mechanism and long-term safety. Soy lecithin, soy products, and alfalfa are good food sources of PEA. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide. For one, a lower FAAH will boost PEA levels as less of it will be broken down. PEA is a compound that the body produces naturally to combat pain and inflammation. However, PEA itself is a plant, and PEA protein is also applied in bodybuilding supplements as a vegetarian source of protein content. [Acute poisoning with weight-loss dietary supplement falsely suggesting the use of amphetamine]. Scientists believe that PEA may act on cannabinoid pathways to reduce pain and inflammation. On the contrary, a diet high in saturated fatty acid will probably only increase your risk for various chronic and inflammatory health problems. It can be found in many different tissues including glia, neurons, retina, white blood cells, mast cells and adipocytes. Fast-forward to the late 1970s, studies started using higher-quality PEA supplements [4]. The highest amounts can be found in soy lecithin, soybeans, egg yolk, peanuts, and alfalfa [1]. It was thought that these benefits result from increased anandamide. 2013;70(10):880-3. In diabetic rats, it reduced eye key inflammatory substances that break down the blood-retinal barrier. SelfDecode provides recommendations that are personalized based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! Palmitoylethanolamide (PEA) belong to endocannabinoid family, a group of fatty acid amides. As a supplement, PEA is available in tablet, capsule, and powder form. In the brain, our natural cannabinoids play diverse roles in behavior, cognition, mood, and seizure risk, among others. Regulations set manufacturing standards for supplements but don’t guarantee that they’re safe or effective. A plus sign next to the number “[1+, 2+, etc...]” means that the information is found within the full scientific study rather than the abstract. Watch Dr. Stewart Explain PEA Nutritional Formula: PEA Soothe Support (Time Release) 60C DISCONTINUED. PEA combined with luteolin was also used in clinical trials. Further clinical trials are needed before we can draw any reliable conclusions. PEA reduced eye nerve damage in over 9 clinical trials used in doses up to 1.8 g/day [20]. It’s also being researched as a supplement, though large-scale data are still lacking. The studies listed below should not be interpreted as supportive of any health benefit. Impaired natural cannabinoids may also play a role in epilepsy. Research indicates it may be vital to supporting the body's natural pain response. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication, or have a medical condition. PEA has been proven to have analgesic and anti-inflammatory activity and has been used in several controlled studies focused on the management of chronic pain among adult patients with different underlying clinical conditions. PEA and the endocannabinoid system is a great example of this concept in action. It is available over the counter without the need of a prescription. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide. The analgesic and antihyperalgesic effects of PEA in two models of acute and persistent pain seemed to be explained at least partly via the de novo neurosteroid synthesis. It may also activate cannabinoid receptors (CB2 and CB1) [2]. PEA is classified as a dietary supplement and has not been approved by the FDA for medical use. PEA (1,200 mg/day) reduced the duration of the cold and symptoms such as fever, headaches, and sore throat in a study of about 900 young soldiers. PEA is a safe food supplement, found in mother's milk, egg yolk and other places. PEA reduced lower back pain in a trial of over 100 people (600 mg PEA/day). This enzyme is called Fatty Acid Amide Hydrolase or simply FAAH. All of our content is written by scientists and people with a strong science background. + Side Effects, High Monocytes? As a fatty acid amine, PEA is broken down by the same enzyme as our natural cannabinoids are. Adelmidrol is an anti-inflammatory substance made by modifying PEA that can also improved IBS symptoms such as diarrhea and weight loss in mice [31]. People report starting out with the standard dosage of 1.2 g/day divided into 600 mg in the morning and 600 mg in the afternoon. Scientists are also investigating the effects of PEA on activating the cannabinoid receptors. These intriguing and recently-discovered molecules are called “neuroactive lipids” [5]. based on YOUR genes to help you stay healthy and avoid infections from viruses like COVID-19! SelfHacked © 2013 – 2021 All Rights Reserved, Ever try supplements that don’t seem to work? In tissues taken by biopsy from people with ulcerative colitis, PEA lowered inflammatory cytokines and the buildup of neutrophils, immune cells that worsen symptoms and contribute to gut damage [2]. Palmitoylethanolamide Reviews. Jonathan Ritter, PharmD, PhD (Pharmacology). But much more research remains to be carried out [1, 4]. Palmitoylethanolamide (PEA) is now available in 300mg Caps in Australia. Some scientists believe this fatty acid may boost natural cannabinoids and protect the nerves. She is a strong advocate of integrating scientific knowledge and holistic medicine. It does not seem like a PEA supplement would be detrimental to take, regardless of severity of symptoms. PEA reduced pain intensity by over 50% in just 3 weeks, which is rarely seen with most painkillers [6]. It’s triggered by inflammatory damage to the nerves in the eye, most commonly caused by glaucoma and diabetes. It may only takes two weeks to achieve pain relief. Also, there is still insuffucient evidence to rate the effectiveness of PEA in people with these types of pain. However, most PEA supplements available to consumers are of synthetic origin. Like the blood-brain barrier protects the brain, this eye barrier is crucial for eye health. Having lower FAAH enzyme activity can offer plenty of benefits. Unlike opiates and other analgesics, PEA works upstream by supporting the healthy function of cells found in the body’s nervous and immune systems. As an endogenous agent and one also found in foods such as eggs and milk, no serious side effects or drug–drug interactions been identified. PEA has always been present in the food supply and is marketed as a dietary supplement. Since 2014 there is also available a new PEA cream, to enhance the effects of PEA also via the thin nerves in the skin. PEA dosage in clinical trials varied from 600 mg to 1200 mg per day. Research shows PEA cell levels are lower after periods of pain and inflammation. The analgesic and anti-inflammatory benefits of PEA make it an ideal candidate for Multiple Sclerosis (MS), which has a strong autoimmune and inflammatory nature. Since the destruction of dopamine neurons is what causes Parkinson’s disease, PEA may be able to prevent this disease or its worsening. Larger, multi-center studies are needed to confirm the effects of PEA on different types of pain [3]. Compared to conventional therapy alone, PEA did not reduce neuropathic pain, spasticity, or insomnia [27]. You will find some of those studies below. PEA might block FAAH and increase cannabinoids. Hence, they do not fall under the category of “natural supplements.” Instead, the FDA considers them unapproved drugs. It nourishes the eye but prevents harmful substances from entering [23, 24]. PEA was typically given over 3 – 8 weeks at dosages between 300 and 1,200 mg/day. There are no known side effects with the use of PEA and is considered suitable for children and elderly people. PEA did not have toxic effects in pregnant animals. Supplementation with PEA encourages the body’s own natural healing and painkilling capacity to do its thing. It shows promise as a painkiller and anti-inflammatory, though large-scale safety and efficacy data are still lacking. Egg yolk is another great food source for people who don’t react to eggs. It also has specific effects similar to drugs commonly used to lower high blood pressure (ACEI). On the other hand, there is also freedom for one to opt for the 90 capsules bottle which is currently being sold at $49.95. We advise caution in pregnant and breastfeeding women due to a lack of clinical data [32]. If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please leave a comment or contact us at [email protected]. Palmitoylethanolamide (PEA) – backed by more than 300+ medical studies, has been shown to be or assist with: Natural pain reliever* Natural anti-inflammatory* Neuroprotective at the cellular level* Muscle recovery and muscle pain* Immune system support* In mice, PEA prevented normal gut tissue from developing cancerous overgrowth [2]. It is involved in a variety of cellular functions in chronic pain and inflammation. Another limitation was that most of these studies lakced a placebo control. In a trial of 56 women, PEA (300 mg/day) relieved pain and improved sexual function over 6 months [, Pain caused by fibromyalgia. Palmitoylethanolamide, or PEA, is produced in the body naturally to combat pain and inflammation. VERY happy with this supplement! The primary benefits include: • Helps Reduce Inflammation and Pain – PEA may reduce complex pain in your body. PEA & depression: Palmitoylethanolamide (PEA) is a well-tolerated dietary supplement first identified as a naturally occuring anti-inflammatory, analgesic & neuro-protective agent isolated from soy, egg yolk & peanut by Kuehl & colleagues over 60 years ago. Our science team is put through the strictest vetting process in the health industry and we often reject applicants who have written articles for many of the largest health websites that are deemed trustworthy. PEA is also available as a supplement, though large-scale studies are still lacking to support its use as a natural painkiller. More high-quality research is needed to determine how effective PEA is at relieving different types of pain. More clinical studies would be beneficial, but limited data suggests that PEA is safe. PEA reduced inflammatory substances (TNF-alpha) and increased endocannabinoids in the skin (2-AG), which altogether strongly diminishes the allergic response [2]. Does Red Clover Reduce Symptoms of Menopause? View abstract. *, Supplementing with PEA has been scientifically shown to naturally assist in the reduction of inflammation and promote natural pain relief and neuroprotective effects. PEA Cure is a joint pain supplement which is available at varying prices in the market. Palmitoylethanolamide was also discovered in soybean lecithin and peanut meal shortly thereafter. Nonetheless, proper safety studies are still lacking. Other than the uses mentioned above, PEA is also recommended for nerve pain as well as a post-surgery analgesic. The effects were noticeable after 30 days and further improved over another month of supplementation [15]. For the damaged heart tissue to recover, proper blood flow needs to be recovered. Remember to speak with a doctor before taking PEA supplements. A couple of studies have used PEA in children without any risks. Scientists think PEA might activate cannabinoid pathways in the body, which is hypothesized to soothe pain. In individuals, PEA helps reduce pain intensity. SelfDecode provides recommendations that are. Overall, studies indicate that PEA as a dietary supplement may help to reduce pain in osteoarthritis, back pain, sciatic pain, carpal tunnel syndrome, diabetic neuropathy, dental pain, vaginal pain, post-herpetic neuralgia, chronic pelvic pain, and fibromyalgia syndrome just to mention a few. What are the Pros of PEA Cure Supplement? Ana received her MS in Pharmacy from the University of Belgrade. Long-term PEA supplementation has not been linked to adverse effects in small-scale studies. The supplement also increased blood levels of PEA and anandamide [26]. PEA is a fatty acid amid like anandamide, the main cannabinoid bliss molecule your body makes. In general, dietary supplements lack solid clinical research. Clinical studies are needed to confirm these findings [16, 17]. PEA: PEA has shown to offer many health benefits particularly as a pain suppressant... Reducing Pain and Inflammation. Joe Cohen won the genetic lottery of bad genes. This molecule is a naturally-occurring component of soybeans, egg yolks, peanuts, and a number of other foods. But scientists are now realizing how important a role PEA plays – it offers some unique benefits, while others overlap with or support our natural cannabinoids [33]. FAAH not only breaks down cannabinoids, PEA, and similar substances but also degrades cannabinoid receptors (CB1 and CB2). Healthy nerves in the eyes are crucial for maintaining proper vision. Palmitoylethanolamide Health Benefits. It helps to relieve pain and discomfort. There are over 500 clinical studies on PEA since 1957, most are related to neuropathic pain and mast cells (inflammation) activation. Certain manufacturers suggest splitting up the total dose into two during the day. SelfDecode is a software tool we created to help you analyze your genetic data. Lukasik-Glebocka M, Sommerfeld K, Tezyk A, et al. In animal and cell-based studies, PEA improved eczema and skin allergies by lowering mast cell activation and blocking the release of histamine [2]. PEA has an affinity for the cannabinoid-like G-coupled receptors, which is why it is often referred to as a non-psychoactive “indirect endocannabinoid.” As a result, PEA has been shown to have neuroprotective, natural anti-inflammatory, and natural pain relieving properties. In experimental animals (mice and rats), PEA: Scientists hope to explore the effects of PEA on diverse types of pain and inflammation in humans in the future. They are continually monitored by our internal peer-review process and if we see anyone making material science errors, we don't let them write for us again. PEA supplementation was safe and didn’t cause any side effects [21]. In a recent study of 58 people with depression, PEA (1.2 g/day) given over 6 weeks greatly and rapidly improved mood and overall symptoms. This is because PEA is produced in the body on-demand and works at the site of injury or tenderness to lower inflammation and turn off the pain signal. Despite achieving good results, the main problem with the initial studies was that egg yolk or other supplements that contained only small amounts of PEA were used. Read on to find out. Heart attacks result from a total blockage of blood vessels leading to the heart. Align your health hacks with your genes for optimal health & cognitive function. While most of the research speaks to PEA’s ability to reduce pain in general, studies often fail to make a distinction between neuropathic and non-neuropathic pain. PEA seemed to relieve pain caused by diverse health conditions. The benefits of PEA for neuropathic pain are less clear due to insuffucient reliable evidence to date. Palmitoylethanolamide (PEA) is an endogenous fatty acid amide naturally produced in the body. Palmitoylethanolamide (PEA) – backed by more than 300+ medical studies, has been shown to be or assist with: Palmitoylethanolamide is a naturally occurring substance produced in the body. In another study, PEA with luteolin enhanced the healing of nerves in mice with spinal cord injuries. This molecule is a naturally-occurring component of soybeans, egg yolks, peanuts, and a number of other foods. Naturally boost your body’s nervous and immune systems with the support it needs and order today!*. Limited research suggests PEA might support brain, heart health, and immune health. The effects of PEA alone on MS has not been investigated yet. PEA was used in doses of 300 mg to 1.8 g/day in clinical studies. PEA can be combined without any difficulties with any other drug, painkiller or supplement. Since then, numerous clinical trials have extracted the substance from various biological materials and validated its efficacy as a nutraceutical… If you really want to dig deeper, your genetic data can offer you a lot of powerful insight. Researchers hypothesize that the best way to get the benefits of PEA are standardized supplements, or alternatively, PEA-rich foods. The below-described studies were conducted only in animals and cells; clinical evidence is lacking. Palmitoylethanolamide (PEA), an endogenous (manufactured by the body) fatty acid amide, is emerging as a new agent in the treatment of pain and inflammation. PEA blocked enzymes and receptors that increase blood pressure by narrowing the blood vessels (angiotensin receptor 1 and angiotensin-converting enzyme) [29]. The gut damage caused by ulcerative colitis increases the risk of cancer. In some cases, it has also been used to treat other conditions, such as headaches, depression, eczema, endometriosis, autism, kidney disease and vulvar pain. Our team comprises of trained MDs, PhDs, pharmacists, qualified scientists, and certified health and wellness specialists. PEA can also activate other receptors that boost cannabinoid activity (TRPV1). People with glaucoma can choose to undergo laser surgery but risk experiencing high eye pressure shortly after that can cause damage. A decent amount of evidence backs up PEA’s ability to reduce complex pain. The following purported benefits are only supported by limited, low-quality clinical studies. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. PEA showed rapid-onset antidepressant effects which need further investigation." Ana has many years of experience in clinical research and health advising.